In Golden Age sf, interstellar crossings are routinely made through hyperspace or with other FTL drives. In some more recent sf, such crossings are made with interstellar ramjets or other STL drives. I need not again list all of Poul Anderson's contributions to these two scenarios. I have just borrowed Bowl Of Heaven by Gergory Benford and Larry Niven from the public library. I will read this work to its conclusion and then its sequel if they hold my attention but they must compete with my current re-immersion in Poul and Karen Anderson's The King Of Ys.
The Prologue of Bowl... reminds me of Anderson's Starfarers. See here. Slower than light interstellar travelers cannot return home either because they will never return to the Solar System or because it will have changed when they return to it. See also Larry Niven's A World Out Of Time.